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Switch to a different molecule entirely tirzepatide (Zepbound), which produced 20.2% average weight loss versus 13.7% for semaglutide over 72 weeks in the SURMOUNT-5 trial

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Lillys triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial

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At steady state, the amount entering your system each week roughly equals the amount being eliminated, creating a predictable baseline level with weekly fluctuations around it