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PYY(3-36) predominantly acts through the Y2 receptor (Y2R) in the hypothalamus to suppress appetite and in peripheral tissues (adipose, skeletal muscle, liver) to enhance insulin sensitivity

Co-intraduodenal infusion of mixed nutrients (carbohydrate, dextrose) and lipid (20% Liposyn) in rats significantly increase GIP secretion in lymph to a greater extent than either nutrient at the same meal caloric value alone, suggesting a synergistic effect (Lu et al., 2008)

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N Engl J Med 351(26):26832693