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The antizyme inhibitors bind to the antizyme proteins thereby blocking their ability to bind ODC and target its degradation by the proteasome

However, conditions caused by genetic mutations that affect growth are associated with a wide range of phenotypic abnormalities that may affect glucose handling, primarily due to diminished pancreatic -cell mass and subsequent intra-portal hypoinsulinemia

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However, Jie Cui et al

These may result in oxidative stress in which molecular signaling is altered