Reference: Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ (2018)
However, physiological concentrations of 1 to 10 mg/mL peptide were measured in leukocytes and in the lumen of crypts of Lieberkhn and have been shown to kill microorganisms in vitro at physiological salt concentrations [132]
doi: 10.1681/ASN.2005090949
Mutating any of these three residues has been shown to completely abolish both the lipase and esterase activities of MGL (57)
Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis
C., & Vasiliou, V