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In settings where non-human primates are unfortunately still the primary model (135), the microfluidic platform provided a relevant alternative for studying the molecular basis of RILI and the relative therapeutic approaches

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Therefore, the immune system and detoxification system cannot function without sufficient levels of GSH

For example, a co-crystallization strategy reveals that ML162 effectively targets all catalytic tetrad residues in GPX4 by interacting with Sec46, Gln81, Trp136, and Asn137, thereby completely obstructing the active site [218]

The abundance of basal NADP(H) in cells is positively related to the resistance to ferroptosis

This happens because glutathione supports the liverthe bodys largest store of glutathionehelping to detoxify heavy metals and other toxins