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The lysed cells were kept at 80 C until analysis and diluted 1:1 in sample diluent

Recalculate before the first draw

Because carnitine is responsible for this crucial step in the generation of ketones, MAD will likely increase demand for carnitine

(107) demonstrated that even though prednisolone increased serum total and bioactive IGF-I, post-IGF-IR signaling was inhibited indicating that prednisolone-induced increases in serum IGF-I levels is not accompanied by increased IGF-I action

2018;20(Suppl 1):5-21

Future work should be focused and lean: enroll truly deficient, higher-risk patients, standardize formulations and dosing, and test event-driven hard endpoints aligned to mechanism, while embedding translational markers to confirm on-target biology