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Here is a framework for thinking through the decision, based on the dosage and outcome data above

Obtaining a liver biopsy may be recommended even when the symptoms are mostly neurologic, or when the diagnosis has been made from blood tests, urinary copper excretion, and genotyping results

Response: We appreciate the commenters' concerns

H.MelchiniA.Coode-BateJ.Al KadhiO.SahaS.DefernezM.et al (2019)

The pain associated with CTS can vary in severity, ranging from mild discomfort to sharp, shooting pains that interfere with daily activities

A sudden loss of strength, deformity, or inability to bear weight may need imaging or urgent injury evaluation