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Zepbound should be used with caution in patients with severe gastrointestinal disease, including gastroparesis

[7] Unlike capsaicin, 6-paradol produces sustained thermogenic effects without receptor desensitization, making it effective for repeated daily use

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The subcutaneous space contains fewer blood vessels than muscle tissue, allowing for slower, more sustained absorption of the medicationa critical feature for tirzepatide's once-weekly dosing schedule

Significantly, their weight continued to decrease even after the trial ended