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C677T polymorphism in the MTHFR gene (A222V, rs1801133) is associated with a decrease in enzymatic activity to 3570% in homozygotes

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10.1007/s00109-013-1105-2 133 MasamhaC

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The potential cardiovascular benefits expected from this new therapeutic approach to obtain glycemic control in T2D arises a possibility to change the excessive cardiovascular burden related to this disease in both developed and developing countries worldwide