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Challenges: modifications are needed to ensure drug can be soluble and stabilized across a range of PH and mediums

There are currently four approved SGLT-2 inhibitors (canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin) that have been approved by the FDA for their use in adults

Diabetic patients are also at an increased risk for vascular problems and hypoglycemia, which can contribute to conditions like NAION

The forecast is developed using historical data on diabetes and obesity prevalence, trends in pharmaceutical treatments, and insights from key industry players involved in the development and distribution of GLP-1 therapies

The recent years, riddled with scandals and betrayals, have diminished trust in both institutions and individuals

The review will adhere to the methodology outlined in the Joanna Briggs Institute Reviewers Manual [2], and will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) [8]