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The resultant opening of voltage-dependent L-type Ca 2+ channels increases the intracellular concentration of Ca 2+ , which also acts as a second messenger, augmenting neurotransmitter release [33]

Structural imaging techniques have revealed that the dorsolateral prefrontal cortex, superior parietal lobule hippocampus, and other parts of the hippocampus are reduced in volume (Doney et al., 2022)

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Whilst both leptin and Ozempic (semaglutide) influence appetite and body weight, semaglutide does not mimic leptin signalling

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Alford, R