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The SUMMIT trial, involving 731 individuals with HFpEF and obesity followed for a median of 104 weeks, revealed a 38% decrease in the composite endpoint of cardiovascular mortality or heart-failure deterioration events (HR: 0.62, 95%CI: 0.41-0.95, P = 0.026), driven primarily by fewer worsening heart-failure events (8.0% vs

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adults with overweight or obesity who initiated GLP-1 therapy between 2019 and 2024

doi: 10.1016/j.bbrc.2018.09.143 37

In a recently published phase II study conducted on 92 T2D patients with a BMI 27 kg/m 2 , a 2.18% decrease in HbA1c and a 15.6% reduction in body weight were confirmed in the group administered CagriSema once a week [102]

Photo by Innerbody Research Though accepting the passage of time and all that comes with it is an entirely valid choice, youre far from alone if youd rather try to fight it, or at least try to reduce its impacts on your physical appearance