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3.4.2 Metabolism-immune-epigenetic crosstalk Inflammatory mediators including TNF- and NF-B activation modulate AR signaling capacity while IL-6 triggers DNA methylation changes that affect spermatogenesis (54)

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The EXPLORER study, which focused on moderately-to-severely active extrarenal SLE, found no significant difference between Rituximab and placebo across primary and secondary endpoints (118)