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While human studies on the effects of DSIP are not definitive, the neuropeptides promotion of slow-wave sleep is reported across several preclinical studies [4]

Subsequent haemodynamic assessments did not show any adverse effects of any of the treatments on heart rate or arterial blood pressure in lean mice receiving treatment for 14 days (Extended Data Fig

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However, despite these promising findings, definitive clinical evidence remains limited

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Conversely, persistent diarrhoea or the presence of blood in stools warrants immediate medical assessment