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Intraocular pressure was assessed in normal rats, and values between 13 and 19 mmHg were considered normal, in accordance with previous rat data ( To assess the effect of retrobulbar administration itself, the values were assessed before retrobulbar application, after retrobulbar application of saline (0.1 ml/each eye), BPC 157 1 g/0.1 ml saline/each eye, or L-NAME 0.5 mg/0.1 ml saline/each eye, at 1, 2, 4, 6, 8, and 10 min thereafter

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The amenability of the gastrointestinal tract to oral intervention makes it uniquely suitable for metabotherapy the use of metabolites for the prevention and treatment of disease

It works on both GLP-1 and GIP receptors, while Wegovy acts on GLP-1 only