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Scientists believe that the same neurochemicals used as antidepressant balance both pain and mood

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By stimulating GLP-1 and GIP receptors simultaneously, tirzepatide slows stomach emptying, increases satiety hormones, and reduces overall appetite drive

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However, the neural mechanisms underlying the efficacy of GLP-1R agonists to reduce cocaine seeking and the role of central GLP-1-producing neural circuits in cocaine seeking are unknown

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