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IGF-1 LR3 is engineered to do the same thing, but for a much longer period of time and without being captured by the proteins that normally limit IGF-1 activity

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Increased blood concentration of homocysteine is another nonspecific biomarker of vitamin B 12 deficiency that has been linked to depressive symptoms in the elderly (108)

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However, much of this is relative because Vitamin B12 is water soluble so a lot of it is wasted and passed by the body