Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, as they reflect whether side effects are bothersome enough to outweigh potential benefits
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When we give it in a pharmacologic dose, it accentuates the satiety effects, lowers blood glucose in those who have high blood glucose, and promotes weight loss
Cannabis, on the other hand, often leads to increased appetite stimulation, commonly referred to as the munchies. This effect arises mainly from THCs interaction with the endocannabinoid system, which can trigger hunger signals even when the body does not need additional food
For moderate to darker skin tones, higher doses around 1200 mg or more might be suggested
JAMA neurology, 71 (5), 543552
