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If you've been stable on semaglutide for 3+ months without further weight loss, have reached your target weight, or experience intolerable nausea and constipation, switching to a dual-mechanism compound like tirzepatide may offer better results

Some prescribers recommend longer gaps, particularly for patients switching from higher semaglutide doses

However, they have different formulations and methods of administration

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However, not all studies were included in each analysis due to lack of reporting on all outcomes by each individual study (see Supplementary Material Tables S5S7)

Contact your healthcare provider if you cannot maintain adequate fluid intake, as this may increase the risk of acute kidney injury