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A pivotal study published in the Journal of Clinical Endocrinology and Metabolism examined GHRH administration in healthy older adults and found significant increases in IGF-1 levels, the primary mediator of growth hormone's anabolic and regenerative effects, alongside improvements in lean body mass and reductions in fat mass over a six-month period

Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2)

NRF2 is reported to have suppressive effects on the lipogenic pathway via inhibiting the activity of LXR 64,70 , a transcription factor that supports lipid synthesis

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