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Overall, statins have a key role in cardiovascular treatment regimens reducing the risk of atherosclerotic diseases with different levels of effectiveness based on underlying risk factors and CVD history

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In one sentence, the mechanism is receptor-mediated: GHRP binding to GHS-R1a activates a Gq/11-coupled phospholipase C cascade that mobilises intracellular calcium and triggers exocytosis of stored GH from the anterior pituitary, independent of hypothalamic GHRH signalling

These findings suggest GLP-1 acts directly on the hypothalamic feeding centers

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