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Chen et al (119) used high levels of GSH reductase in the TME and showed that the disulfide bond (-SS-) in SSBPEI-DOX could be specifically reduced, allowing it to bind to the conventional chemotherapeutic drug DOX and induce apoptosis or necrosis of CSCs

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However, levels naturally decline with age, stress, and environmental toxins

10.1186/s12951-022-01595-3 J