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Both tirzepatide and retatrutide have undergone rigorous clinical trials, and the weight loss data from these studies provides the most reliable comparison available

Highly active or very lean individuals may benefit from even higher protein (sometimes up to ~1.62.2 g/kg in rigorous dieting conditions), but for most people about 1.2 g/kg is a solid target to start with

It also includes most of the amount the drug manufacturer pays for brand name drugs while you are in the coverage gap

They are rarely a cause for concern

Here are some of the key benefits beyond weight loss: Reduced cardiovascular risk Lower cholesterol levels Improved blood sugar control Decreased visceral fat (aka hormone belly) Reduced stress and anxiety Does Semaglutide Work Without Lifestyle Changes

No doubt other manufacturers of GLP-1 drugs like Mounjaro, Ozempic, and Wegovy are lining up for similar approvals and extending approvals for other diseases correlated with weight gain