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Specifically, genes related to lipid storage (CD36 molecule ( Cd36 ), sterol regulatory element binding protein ( Srebp )) and adipocyte differentiation (peroxisome proliferator activated receptor gamma ( Pparg )) are significantly downregulated with reduced CNS GIPR signalling 46

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Clinical and observational studies tentatively confirm these findings, especially among people with concomitant obesity or insulin resistance [83]

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