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Other in vitro studies suggest that gliadin itself increases intestinal permeability indirectly by promoting the release of zonulin, a protein that induces TJ disassembly and is present in the submucosa of active coeliac patients at concentrations sixfold greater than healthy controls (Fasano et al

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Intramuscular injection is not appropriate

Senescent oocytes exhibit a decrease in ATP levels, reduced energy production capacity, and decreased mitochondrial function [76,77,78]

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