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Rita Nogueira-Ferreira acknowledges FCT for the research contract CEECIND/03935/2021 under the CEEC Individual 2021 ( Ethics declarations Conflicts of interest The authors declare no competing interests

doi: 10.3233/JAD-190083, 147

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Conclusion In this study, we have identified a ~0.187% level of drug-tolerant persister cells with the CRC cell lines response to anticancer drugs, and we determined that there were G0/G1 cell cycle arrest, and upregulation of stemness factors and mesenchymal-like gene expression in the DTP cells

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