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They are used to treat type 2 diabetes or obesity
A lower dose of one or both medications may be necessary to lessen risks of side effects like nausea, fatigue, or dizziness
The effect on energy intake is consistent with previous data from nonclinical37 and clinical studies with other GLP1RAs,38, 39 as well as studies with native GLP1,3 with the reduction in energy intake correlating with reduction in body weight.3, 38, 39 However, the effects with semaglutide appear to be greater than those of other GLP1RAs, consistent with larger weight reductions observed in larger semaglutide trials of longer duration;40 however, caution is required when drawing an indirect comparison between trials