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Simultaneously, PSP exhibited potential to ameliorate depressive-like behavior by inhibiting ERK phosphorylation-mediated NF-B activation and modulating inflammatory responses (Shen et al., 2021)

In HO-exposed cells, melatonin pretreatment markedly restored the compromised mitochondrial membrane potential, as indicated by TMRM fluorescence

Also, iron overload affects energy balance and metabolism, especially in adipocytes

Additionally, it increases beta-adrenergic receptor expression, enhancing fat breakdown sensitivity, making it a promising candidate for obesity treatment (2)

doi: 10.2174/1381612823666170220163219

They then compared these changes with those found in the pre-frontal cortex Brodmann Area 9 (BA9), a relatively unaffected tissue