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Protect from reducing agents and direct light

Based on the fitted pKa of 6.87, which is in good agreement with the average of 6.52 from other reported values (11, 5759), the amount of niclosamide in aqueous solution increases in the higher pH range (of 8-9.5)

Hormone and metabolic modulators

The 13-amino-acid N-terminal extension (sequence MFPAMPLLSLFVN) shifts the three-dimensional conformation of the binding interface, while the Arg 3 Glu 3 substitution disrupts a key contact residue with IGFBPs

Cochrane Database of Systematic Reviews , 2019(10)

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