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A small study of five infants with severe generalized JEB with at least one premature truncating pathogenic variant in LAMB3 evaluated the clinical effects of treatment with gentamicin (7.5 mg/kg/day for 3 weeks) on skin fragility and other clinical features

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One method of restoring normal intestinal microbiota is fecal microbiota transplantation (FMT)

It appeared as the first in-line synthetic peptide that specifically triggered growth hormone release in a dose-dependent manner, both in cell cultures and in living organisms

The compound has been studied across multiple tissue contexts (tendon, ligament, muscle, gastrointestinal, vascular)