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GLP-1/GIP agonists could trigger an immune response in the liver, leading to hepatocyte damage and bile duct obstruction
The GLP-1 diet approach works best when combined with nutritious foods that support the medications effects something many doctors dont adequately explain to patients
Seek medical advice if fatigue: Persists beyond several months without improvement, despite adequate nutrition and hydration Worsens progressively or becomes debilitating, significantly impairing daily activities or work capacity Is accompanied by severe or persistent gastrointestinal symptoms (intractable nausea, vomiting, diarrhoea, abdominal pain) Occurs alongside signs of dehydration (dark urine, dizziness, reduced urine output, dry mouth) Is associated with symptoms of hypoglycaemia (tremor, sweating, confusion, palpitations), particularly in patients taking concurrent insulin or sulphonylureas Urgent medical attention is required if patients experience: Severe abdominal pain , especially if radiating to the back, which may indicate pancreatitisa rare but serious adverse effect of GLP-1 medications
So, why does GLP-1 cause fatigue
Mechanistically, GLP-1 can lower BP through a diuretic mechanism, and other effects on the kidneys [39, 40]
Since several studies document a decrease in adherence as therapeutic complexity increases, an improvement in therapeutic adherence can be expected with the use of this drug, especially considering the excellent results that patients can achieve in terms of weight reduction
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