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By enhancing Hedgehog, transforming growth factor beta (TGF-), Wnt/-catenin, mammalian target of rapamycin (mTOR), and MAPK/protein kinase A (PKA) signaling, PTH-1R activation by PTH administration plays a protective role in NP cell activity and disc homeostasis (6972, 74)

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Brand-name pens have a 21-day limit at room temperature