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After DWI denoising and artifacts correction, white matter structure was assessed using Diffusion Tensor Imaging (DTI) parameters, including free water correction (FW-DTI), and advanced diffusion descriptors obtained with novel techniques, AMURA and MISFIT, in the regions from the JHU ICBM-DTI-81 Atlas with volume higher than 2000 mm 3 (28 regions)

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Acknowledgments The authors would like to thank the magnetic resonance imaging technologists for their valuable assistance in acquiring the imaging data

While consistent medication use improves outcomes, it also increases claims costs because of prolonged exposure to high monthly drug prices