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22.Kushner RF, Calanna S, Davies M, et al

TRIUMPH-4 Phase 3 data showed 28.7% mean weight loss (71.2 pounds) at 48 weeks, a result that, if replicated in registrational trials, would redefine the efficacy ceiling for the class

41 Similarly, Aronne et al reported that in overweight or obese individuals, most of the weight lost during tirzepatide therapy was regained after treatment discontinuation

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Despite decades of lifestyle-based interventions, long-term weight loss has proven elusive for many, driving an urgent need for safe and effective medical therapies

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