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Sirtuins (SIRTs) are a protein family with versatile functions, such as metabolic control, epigenetic modification and lifespan extension [31]

10.1111/j.1750-3639.2011.00546.x 60 ChiL.KeY.LuoC.GozalD.LiuR

reported that the protein kinase r-like endoplasmic reticulum kinase (PERK), activating transcription factor 4 (ATF4), and the C/EBP homologous protein (CHOP) expressions were increased and Fe 2+ concentrations were elevated in rats with ischemia/reperfusion lung injury, suggesting that this injury may trigger iron-dependent cell death by activating the endoplasmic reticulum

Notice that either O atom in methanoic acid can serve as a H-bond acceptor