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To minimize this, doctors often advise taking PT-141 on an empty stomach (food can sometimes exacerbate nausea) and perhaps taking an over-the-counter anti-nausea drug if needed

doi: 10.1038/mi.2014.124 93 SunHShuJTangJLiYQiuJDingZet al

After LPL hydrolyzes TRLs, sortilin, a member of the vacuolar protein sorting 10 (or VPS10) family, facilitates the uptake of secreted LPL and transfers it to endosomes in parenchymal cells, and LPL ends up in lysosomes for degradation [50,84]

The primers used were: 53 F (AAAGCTAGCGCCACCATGAAGACGATCATCGCCCTGAGC) and 53 R (TTTGGCGCGCCCTAA-GAGCAGGACGCCTGACAAGT), ligating the product into pAAV-hSyn-DIO-EGFP (plasmid from Addgene, 50457, RRID: Addgene_50457) in place of the EGFP in NheI and AscI sites to produce the human GLP1R virus construct (AAV-hSyn-DIO-hGLP1R)

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