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Sources: EMBRAZE Phase 2 press release Scholar Rock, June 2025 EMBRAZE full publication Nature Medicine, 2026 BELIEVE trial: bimagrumab + semaglutide HCPLive, May 2026 Lilly pauses bimagrumab trial BioPharma Dive, Sept

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122 Recently, glucagon was also reported to have a positive effect on bone metabolism in T2D patients implying that this hormone increases the rate of skeletal modelling

That's a reason to keep on top of your nutrition and strength-training while on these drugs, he writes, "especially for older people like me, who are [already] susceptible to muscle loss." There are people who should steer clear of GLP-1 drugs, Kessler notes, including those with a personal or familial history of certain thyroid and endocrine cancers, those with chronic kidney disease, pancreatitis, inflammatory bowel diseases, uncontrolled diarrhea or constipation or gastroparesis, or if you are pregnant

Hormonal effects from Pendulum have not been specifically studied, but GLP-1 has documented interactions with reproductive hormones