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The PCE of retatrutide but not the PCE of isoprenaline were attenuated by H89, an inhibitor of the cAMP-dependent protein kinase (PKA)

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Moreover, Glp1r Tie2/ mice do not display differences in renal artery or kidney Glp1r expression, as opposed to Glp1r VSM/ mice in which Glp1r expression is markedly reduced in these structures, further highlighting that VSMCs are the main renal GLP-1Rexpressing cell type

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