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Animals were treated with Dox and/or NMN, and 8 weeks later were stimulated with pregnant mares serum gonadotrophin (PMSG), with the number of germinal vesicle (GV) stage cumulus oocyte complexes (COCs) recovered from ovarian antral follicles used as a readout for oocyte yield (Fig

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Taken together, these findings suggest that IGF-1-mediated regulation of protein metabolism in humans cannot be excluded as a possible mechanism, although LC supplementation may affect muscle protein balance in people with low circulating IGF-1 level

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