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When gut inflammation disrupts tryptophan metabolism, shunting it toward the kynurenine pathway instead of serotonin synthesis, the brain experiences a serotonin deficit even when dietary tryptophan intake is adequate

doi: 10.1016/j.rbmo.2017.08.018 225 AboulfoutouhIYoussefMKhattabS

In contrast, those exposed to other cellular stimulants like insulin revealed lower viability, which in some cases displayed the potential to drop below 50%