AAFCO (2015) Official Publication of the Association of American Feed Control Officials Inc., Champaign, IL
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Renal Impairment In a study of patients with end stage renal impairment, mean elimination half-life was prolonged in uremic patients due to increased volume of distribution and reduced clearance
APAP metabolism is chiefly performed by the parenchymal liver cells, hepatocytes, and results in the formation of various byproducts including N -acetyl- p -benzoquinone imine (NAPQI), which is highly cytotoxic 21,22
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