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Evidence has demonstrated that local sterile meningeal inflammation plays a role in inducing prolonged activation and sensitization of meningeal afferents (5)

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Despite extensive research, disease-modifying treatments remain elusive, with current management primarily focusing on symptom control

All the abnormalities of the developing brain elicited by prenatal ethanol exposure (PNEE) imply behavioral changes

Result: no significant change in erythrocyte glutathione levels, hepatic glutathione (measured via biopsy in a subset), or markers of oxidative stress

Using a 1:100 ratio of mg tissue to L KME buffer (20 mM MOPS, 120 mM KCl, and 1 mM EGTA, pH 7.4), tissue was homogenized in 2 s bursts separated by a 2 s rest for a total of 10 s (or 3 cycles) at 16,600 rpm using IKA T25 digital Ultra-Turrax homogenizer