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However, with IBD-current biologic therapies, all these mean some patients primary non-responders, experience a loss of response, intolerance or side effects, defining the urgent unmet need for novel treatments (13, 14)

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For example, sleep acutely attenuates abnormalities in sensory gating in schizophrenia [59] and similar sensory gating deficits that emerge in non-schizophrenics voluntarily undergoing habitual sleep restriction [60]

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