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Deep peels, often containing phenol, reach the deeper layers of the skin and can produce dramatic results by removing significant pigmentation and even reducing fine lines

These might act peripherally (i.e., bile duct ligation), centrally (i.e., huge intraventricular hemorrhage), and then peripherally and centrally, and centrally and peripherally, along with the three interconnected body cavities, as specifically shown in the maintained intra-abdominal hypertension studies [22], as the disturbances may be rapidly transmitted from the periphery to centrally, and from centrally to the periphery, through the venous system

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[PubMed] [Google Scholar] 13.Ueland PM, Refsum H, Stabler SP, et al

Prins JB, van der Meer JW, Bleijenberg G

Comment on the letter by Sadighha and Zahed on Hair darkening after treatment with cyclosporin in a patient with psoriasis