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Outcomes of interest included quality-adjusted life years (QALYs), total costs (from the Australian public healthcare perspective) and the incremental cost-effectiveness ratio (ICER)

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Dose Escalation Timeline After the initial four weeks at 2mg, the dosing increases in a structured pattern: Each increase happens after four weeks, assuming youre tolerating the current dose well

PMID: 257 YangFYanQWangYLiQWangJZengXet al