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It belongs to a class of medications called glucose-like peptide 1 (GLP-1) receptor agonists

This work was supported by the National Health and Medical Research Council of Australia (NHMRC) Project grants (1006141, 10305133, 1086887, and 1095215)

After: In just under two months, he dropped to 195 lbs and lost two inches around his waist

Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure

The improvement in kidney function was consistently observed in sensitivity analyses using alternative equations to estimate eGFR, but using the creatinine-based formulas, there was a statistically significant decrease in eGFR versus placebo at 12 weeks, which again reversed by 52 weeks, showing an improvement in eGFR with tirzepatide across all estimates (Extended Data Table 1)