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Their clinical model relies on standard prescriber evaluation and protocol-based dosing

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The pathogenic roles of LMNA (E358K) and LMNA (R453W) were previously reported to cause muscular laminopathy including CMD, EDMD, and EDMD2, our results confirm the pathological roles of LMNA (E358K) and LMNA (R453W) variants and suggest that the novel variants LMNA (L35P) and LMNA (A539V) may also have pathogenic implications

When these comorbidities resolve or improve, documentation should reflect the change (code the resolved condition with appropriate Z codes, or continue coding the chronic condition if still clinically present)

3 Thus, the significant weight loss and metabolic benefits of GLP-1 RAs are partly due to neurological mechanisms that may have therapeutic implications beyond weight loss and diabetes management