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however, clinical treatment still faces numerous challenges: 30%-40% of patients exhibit primary or secondary non-response to existing therapeutic regimens such as biologics and small-molecule drugs, and prolonged administration tends to induce significant side effects

"Poly-agonist approaches to metabolic disease: mechanisms and clinical potential." Obesity

American Journal of Hospice and Palliative Medicine

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Diagnosis Diagnosis typically involves a thorough clinical examination, including assessment of muscle strength, sensory function, and reflexes