Among the proposed mechanisms, dysregulation of lipid metabolism appears to be a leading factor
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Published data demonstrate that when type 2 diabetics are put on the a dietary program that was consistent with the Zone diet in both the levels of calorie restriction (1,200 to 1,500 calories per day) and a macronutrient composition (40% carbohydrates, 30% protein, and 30% fat) the result was not only is there complete remission of their diabetes, but also an increase in their lean body mass (7)
Their insufficient insulin secretion in response to glucose stimulation highlights the need for further protocol optimization before clinical translation can be considered a feasible approach [35, 48]
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