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J Am Acad Orthop Surg Glob Res Rev

Inconsistently with previous results, a small randomized phase II clinical trial on thirty patients concluded that addition of pravastatin to epirubicin, cisplatin, and capecitabine did not improve the clinical outcome of the enrolled patients with advanced gastric cancer [93]

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Interestingly, investigations into the genetic variance risk related to intrinsic inhibition of TNF or TNFR1-TNF have found no correlation between the age of onset of PD and inhibition of this pathway, indicating that further research is needed to understand the role of necrosis in disease development (Kang et al., 2021)